[Budget Impact Analysis of the Adjuvanted Quadrivalent Influenza Vaccine in the Elderly in Italy]

BACKGROUND: Vaccination is the most effective way to prevent influenza and its complications. The MF59-adjuvanted quadrivalent (aQIV) high-dose (QIV-HD) vaccines have been specifically developed protect subjects aged ≥65 years. aim of this study was evaluate economic consequences associated with use aQIV in elderly population Italy.METHODS: An Excel-based budget impact model estimate costs for prevention complications subjects, from perspective Italian National Health Service. In base-case analysis a current scenario (with aQIV) compared past (without aQIV), which only standard vaccine (QIV-STD) available. analysis, future (hypothetical) scenario, market share grows. Efficacy (or effectiveness) data vaccines, terms reduction influenza-related deaths hospitalizations influenza/pneumonia, respiratory, cardiac complications, were obtained scientific literature. Relative effectiveness QIV-HD vs. QIV-STD preventing laboratory-confirmed cases came two meta-analysis real-world studies. Epidemiological unit are collected published sources.RESULTS: introduction e influenza-like illness – ILI (-93,171) cases, hospitalization influenza, respiratory cardiovascular (-6,823), (-1,841) consequent saving € 1.9 million 24 related events hospital admissions avoided, respectively. growth shares 13,602 fewer ILI, 996 hospitalizations, an overall equal 3.8 million.CONCLUSIONS: reduces number or